Livagen 20mg (Bioregulator)
Livagen is a short bioregulatory peptide that has direct effects on DNA structure and function. It is best known for its ability to decondense chromatin, thereby increasing the expression of certain genes and improving the “youthful” profile of cells. Its most studied effects are on lymphocytes of the immune system. Through these cells, Livagen has been shown to activate the immune system and offset disease in the heart, GI tract, immune system, and central nervous system. Livagen research has also shown promise in the area of nociception and pain control. Ongoing research will help to further unravel the promise of Livagen and bring humanity closer to understanding the processes of aging and senescence.
$65.00
Livagen
Livagen, a short peptide closely related to Epitalon (aka Epithalon), is known for its effects on the immune system, GI tract, and liver. As a peptide bioregulator, Livagen has direct effects on DNA and gene expression patterns. Its purported anti-aging properties are thought to result from Livagen’s ability to activate genes in the GI tract and immune system that are otherwise silenced as a result of DNA condensation with age.
Livagen Structure
Amino Acid Sequence: Lys-Glu-Asp-Ala
Molecular Formula: C18H31N5O9
Molecular Weight: 461.5 g/mol
PubChem CID: 87919683
CAS No: 195875-84-4 (Deprecated: 402856-42-2)
Alternative Names: SCHEMBL5967826
Source: PubChem
Livagen, Chromatin, and the Immune System
DNA is contained within the nucleus of eukaryotes, like humans, in a hierarchy of ever more condensed organization that takes the roughly 3 feet of DNA that is contained within a human cell and packages it to fit within the space of one hundredth of a millimeter. In other words, the packaging of DNA reduces its overall size by about 100,000 times.
The double helix of DNA is wrapped around proteins, called histones, which themselves conglomerate to form chromatin structure, which further condenses to form chromosomes. This progressive organization of DNA serves several purposes including condensing the genetic material for replication and cell division, condensing the genetic material so that it fits within cells, and controlling expression of genes at a very high level. In other words, DNA organization is all about packaging the genetic material and about controlling access to specific genes[1].
The latter function of chromatin, controlling gene expression,
Source: NIH
Research in older adults suggests that Livagen activates a number of genes in the lymphocytes of older people by inducing the decondensation (unpacking) of chromatin. This results in the activation of genes that are otherwise silent in older adults including ribosomal genes responsible, indirectly, for robust protein production and enhanced cell activity[2]. This information suggests that Livagen has a direct effect on the DNA within lymphocytes, which are a primary cell of the immune system.
Research looking that the end-points of Livagen, Epitalon, and Vilon administration in elderly individuals shows that Livagen has four different effects in lymphocytes including
• activating synthetic processes by reactivating ribosomal genes,
• unpacking chromatin,
• altering gene expression, and
• inducing decondensation.
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